Don't
be so quick to toss those pills
Two more blood
pressure medications have joined the growing list of recalled drugs. The
combination drugs amlodipine/valsartan
and amlodipine/valsartan/hydrochlorothiazide join valsartan, losartan and
irbesartan—all
facing recalls because they may contain substances that cause cancer.
You might think that
the safest thing to do is to stop taking your medication if it’s been recalled.
But that’s not necessarily true.
“The reason they are being recalled is there’s
something in them that may theoretically cause you to have a problem. It may
cause cancer in the future,” says Kathryn Boling, MD, a family medicine physician
with Mercy Medical Center in Lutherville, MD.
Yet the dangers of
high blood pressure likely outweighs the risks of cancer from the recalled
medications.
“Stopping your
medication and having your blood pressure shoot up right now is a real-time
risk of stroke, heart disease, and kidney damage,” she says. “That’s why you
should keep taking it until you get a replacement. It’s a theoretical risk vs.
a real risk to your life.”
John Osborne, MD, a
cardiologist in Dallas, TX, agrees.
“Uncontrolled high
blood pressure is 100% clearly a killer,” he says. “It’s orders of magnitude
higher risk than the theoretical risk of this contaminant.”
What are the dangers
of high blood pressure?
According to the American Heart Association,
more than two-thirds of adults in the US over age 60 have high blood
pressure.
It’s important to
keep your blood pressure under control—the higher your readings, the greater your
risk.
Every time your top
(systolic) number goes up by 20 mmHg, or your bottom (diastolic) number goes up
by 10 mmHg, you double your risk of death due to stroke, heart disease, or
vascular disease.
What’s the actual
risk of cancer?
A study of NDMA,
the substance found in some lots of valsartan, was published in the
international research journal The BMJ
in September. It didn’t find a significant increase in cancer in the short
term. But it warned that longer-term studies are needed.
The FDA estimates
that if 8,000 people took the highest dose of valsartan for four years (many
people take lower doses), one additional
cancer case might occur.
There’s less data
available on NDEA, a substance found in all three recalled drugs. It’s known to
cause cancer in animals, and the Environmental Protection Agency considers it a
probable human carcinogen.
Does the recall
affect you?
Only certain lots of
each medication are being recalled. Boling says that most people won’t be able
to tell whether their medication was recalled just by looking at the
bottle.
“The first step is to
check with your pharmacist,” she says. “Only your pharmacist knows. Your doctor
doesn’t know where the drug was ordered from.”
If your pharmacist
says your drug was recalled, talk to your doctor. He or she can help you find
another version of that drug, or another drug that you can take instead. That
way you can limit the time you’re taking the recalled medication.
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