Atvb
Journal Report American Heart
Association News
Release 16-Jan-2020
DALLAS, Jan. 16, 2019 - For the first time, in
a study conducted in mice, researchers found that tobacco smoke from a hookah
caused blood to function abnormally and be more likely to clot and quickly form
blood clots, which can increase the risk of heart attack or stroke, according
to new research published today in the American Heart Association's
journal Arteriosclerosis, Thrombosis and Vascular Biology (ATVB).
Researchers found that tobacco smoke from a
hookah caused blood clots to form within an average of about 11 seconds,
compared to an average of 5 minutes for clotting without exposure to hookah
smoke. Exposure to the hookah smoke also caused other abnormalities related to
the way the blood flows.
"Hookah smoking, which is becoming more
popular in Western countries, is perceived as less harmful than cigarettes, yet
hookahs carry a toxic profile that is thought to be comparable or to even
exceed that of traditional cigarettes. Some studies have found that the smoke
emitted from one hookah tobacco smoking episode contains significantly more
harmful chemicals compared to a single cigarette," said Fadi Khasawneh,
Ph.D., associate professor and chair of pharmaceutical sciences at The
University of Texas at El Paso.
Hookah, also known as waterpipe smoking, is a
unique method of smoking tobacco. It consists of a head (which holds the
tobacco), a body, a chamber filled with water, a hose and a mouthpiece.
Charcoal briquettes are used to "burn" the tobacco.
In this study, researchers exposed mice to
hookah smoke from a smoking machine that mimicked real-life smoking habits. The
smoking machine used 12 grams of commercially available, flavored tobacco that
included tobacco, glycerin, molasses and natural flavor with nicotine and tar.
Researchers then compared platelet activity among the exposed vs. the unexposed
mice.
The study simulated the type of nicotine
exposure that occurs with smoking a hookah, which the researchers verified by
measuring the levels of cotinine, the nicotine metabolite.
"Our findings provide new evidence that
hookah smoking is as unhealthy - if not more so - than traditional
cigarettes," Khasawneh said. "Smoking a hookah, cigarettes,
e-cigarettes or other forms of tobacco all increase your risk for heart disease
and stroke."
In May 2019, the American Heart Association
published a Scientific Statement, "Water Pipe (Hookah) Smoking and
Cardiovascular Disease Risk," to analyze available research on the health
effects of hookah smoking. The Statement notes that hookah smoking results in
inhaling significant levels of toxic chemicals such as carbon monoxide and
particulates from tobacco that can harm blood vessels, the heart and lungs, as
well as creating a dependence on nicotine.
"This study provides additional evidence
that, contrary to popular belief, hookah smoking adversely affects
cardiovascular health. From 2011 to 2015, the number of United States-based
waterpipe establishments is estimated to have more than doubled, and interest
has grown among both teens and adults," said Aruni Bhatnagar, Ph.D., chair
of the Scientific Statement writing group. "Although the tobacco industry
has found novel ways to popularize and increase the use of new products,
studies like this highlight the high risk of hookah smoking."
###
Co-authors are Ahmed Alarabi, M.D., M.P.H.;
Zubair Karim, Ph.D.; Jean Ramirez, M.S.; Keziah Hernandez, M.P.A.; Patricia
Lozano, M.S.; Jose Rivera, Pharm.D.; and co-leader of the study Fatima
Alshbool, Pharm.D., Ph.D. Author disclosures are in the manuscript.
The National Institute of Environmental Health
Sciences and the National Heart, Lung, and Blood Institute of the National
Institutes of Health partially funded the study.
Additional Resources:
Available multimedia is on right column of
release link: https://newsroom.heart.org/news/hookah-smoke-may-be-associated-with-increased-risk-of-blood-clots?preview=af107c8b13edca33d551ee5949d6a212
After 4 a.m. CT / 5 a.m. ET Thursday, Jan. 16,
2019, view the manuscript online.
Statements and conclusions of study authors
published in American Heart Association scientific journals are solely those of
the study authors and do not necessarily reflect the Association's policy or
position. The Association makes no representation or guarantee as to their
accuracy or reliability. The Association receives funding primarily from
individuals; foundations and corporations (including pharmaceutical, device
manufacturers and other companies) also make donations and fund specific
Association programs and events. The Association has strict policies to prevent
these relationships from influencing the science content. Revenues from
pharmaceutical and device corporations and health insurance providers are
available at https://www.heart.org/en/about-us/aha-financial-information.
About the American Heart Association
The American Heart Association is a relentless
force for a world of longer, healthier lives. We are dedicated to ensuring
equitable health in all communities. Through collaboration with numerous
organizations, and powered by millions of volunteers, we fund innovative
research, advocate for the public's health and share lifesaving resources. The
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https://www.eurekalert.org/pub_releases/2020-01/aha-hsm011320.php
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