by Angela Maas
On May 27, the FDA gave an additional indication to Bristol
Myers Squibb's Zeposia (ozanimod) for the treatment of adults with moderately
to severely active ulcerative colitis. It is the first and only sphingosine
1-phosphate (S1P) receptor modulator approved for this indication. However,
according to payers responding to a survey by Zitter Insights, the treatment
may have some challenges breaking into the space.
How much will Zeposia cost?
- Treatment is initiated with a 0.23 mg dose once daily
on days one through four, then 0.46 mg once daily on days five through
seven and then 0.92 mg once daily afterwards. The price of a starter kit
consisting of the initial 37-day supply is $9,110, and a 30-day supply is
$7,387 for an annual wholesale acquisition cost of just under $90,000.
How will payers manage Zeposia?
- For the Managed Care Biologics & Injectables Index:
Q3 2020, between Aug. 25, 2020, and Sept. 28, 2020, Zitter Insights polled
50 commercial payers with 127.5 million covered lives. Payers with 67% of
covered lives said they are unlikely to prefer Zeposia over other
therapies approved for ulcerative colitis or to incentivize physicians to
prescribe it. Almost one-quarter said they are likely to exclude it from
formulary.
How will gastroenterologists prescribe Zeposia?
- During the same time frame, Zitter Insights polled 50
gastroenterologists about their anticipated prescribing of Zeposia. Almost
two-thirds said that they are likely to prescribe the agent for people
with ulcerative colitis who had not responded to a previous treatment, and
more than half said they are unlikely to prescribe the new drug as a
first-line therapy for ulcerative colitis.
- Almost half said they would prescribe it over certain
agents in the class, with those respondents citing AbbVie Inc.'s Humira
(adalimumab) and Simponi (golimumab) from Janssen Biotech, Inc., a Johnson
& Johnson company, as the drugs they were likely to prescribe instead
of Zeposia.
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