Even though drug manufacturer discounts and rebates have been
rising, when wholesale list prices for prescription drugs more than doubled
over a period of seven years, that still triggered large increases in patient
out-of-pocket costs and insurer payments, according to a recent study published
in JAMA Network Open. The researchers analyzed pharmacy claims for five
patent-protected specialty drugs and nine brand-name drugs associated with the
highest total expenditures by commercial insurers in 2014, and found that their
average wholesale price (AWP) increased by 129% from 2010 to 2016. Median
insurer expenditures on the 14 drugs analyzed grew 64%, while median patient
out-of-pocket costs went up 53% during that time.

NOTE: All results have been adjusted to 2016 dollars using the
Consumer Price Index.
SOURCE: "Changes in Drug List Prices and Amounts Paid by Patients and
Insurers," JAMA Network Open. 2020;3(12):e2028510.
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